A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans.
نویسندگان
چکیده
We demonstrate the quartz crystal microbalance as a novel method to quantify the reaction yields and stability of the terminal conjugation of chemically complex molecules. Oxime ligation is identified as a facile, broadly applicable method for the reducing-end conjugation of glycosaminoglycans that overcomes the limited stability and yield of popular hydrazone ligation.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 96 شماره
صفحات -
تاریخ انتشار 2014